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Instructions below are for Ubuntu 21.10, but should work for most versions of Linux based on the gnome desktop.
Large Text will increase the size of text found in menus, icons, and certain applications. However, some text may not become bigger, especially text found in applications that use custom toolkits or toolkits from another desktop environment such as KDE. The size of large the text cannot be adjusted from the accessibility settings screen.
Pro-tip: turn the Fractional Scaling toggle on to get more options for screen scaling.
Display scaling will increase the size of text no matter the application, however it will increase the size of everything including images, icons and apps as well. Explore the different percentages to find one that works best for you.
Changing the color of the mouse pointer in Ubuntu is possible, but requires knowledge of the command line interface.
Dark mode replaces the standard light background & dark text system theme with a dark background light text theme which can make text easier to read for some individuals and may reduce eyestrain.
The selected theme cannot be customized.
Night Light reduces the blue light emitted from the computer screen. Reducing blue light may reduce eye strain when used in dimly lit or dark settings.
Zoom can enlarge the entire screen, or parts of it as needed. Options can be adjusted from the settings menu.
On the Web: hold CTRL and press the + key to zoom in.
Use this shortcut to quickly increase the size of the text in any web browser.
Orca is a screen reader designed to support individuals who are blind or who have limited vision.
The visual alerts feature can be set to flash the active window or the entire screen when an alert sound occurs. This is useful for people who would not be able to hear the alert.
Sticky keys is designed to enable one handed activation of multi-key combinations such as CTRL+ P (print) or Alt + Tab (switch windows). The feature holds down each system key (CTRL, ALT, Shift or Windows) until an alpha-numeric key is pressed.
Slow Keys can be used to ignore brief or repeated keystrokes by increasing the time required between key press and activation which may be useful for people who have difficulty targeting keys or who have a tremor in their hands.
Bounce Keys can be used to prevent accidental repeated keystrokes by increasing the time required between accepting key presses.
Mouse Keys enables use of the keyboard to control the mouse pointer.
Click assist provides two features that makes using the mouse easier for someone who has difficulty clicking the standard mouse buttons.